UBFQQO

Sección de Química Orgánica

Departamento de Química Inorgánica y Orgánica

Capítulos de libro


Basic research Modern Methods in Stereoselective Aldol Reactions
by Rainer Mahrwald Editor
Chapter 1. Stereoselective Acetate Aldol Reactions
Pedro Romea and Fèlix Urpí.
Pages 1-81
Wiley, 2013


Organic Syntheses
Stereoselective Synthesis of anti α-Methyl-β-Methoxy Carboxylic Compounds
Pedro Romea and Fèlix Urpí.
Volume 90
Pages 182-189
Organic Syntheses, 2013

e-EROS Encyclopedia of Reagents for Organic Synthesis
Trichlorotitanium isopropoxide
Pedro Romea and Fèlix Urpí.
e-EROS, 2008


Artículos


84. Direct and Asymmetric Aldol Reactions of N-Azidoacetyl-1,3-thiazolidine-2-thione Catalyzed by Chiral Nickel(II) Complexes. A New Approach to the Synthesis of β-Hydroxy-α-Amino Acids
Teloxa, S. F.; Mellado-Hidalgo, M.; Kennington, S. C. D.; Romea, P.; Urpí, F.; Aullón, G.; Font-Bardia, M.
Chem. Eur. J. 2022, 28, in press.
83. Synthesis of [(R)-DTBM-SEGPHOS]NiCl2 for the Enantioselective Acetal Formation from N-Propanoyl-1,3-Thiazinane-2-thione and Trimethyl Orthoformate
Kennington, S. C. D.; Romea, P.; Urpí, F.
Org. Synth. 2022, 99, 1-14.
82. Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters
Pérez-Palau, M.; Sanosa, N.; Romea, P.; Urpí, F.; López, R.; Gómez-Bengoa, E.; Font-Bardia, M.
Org. Lett. 2021, 23, 8852-8856.
81. Synthesis and Acylation of 1,3-Thiazinane-2-thione
Kennington, S. C. D.; Galeote, O.; Mellado-Hidalgo, M.; Romea, P.; Urpí, F.
Org. Synth. 2021, 98, 374-390.
80. Direct, Enantioselective, and Nickel(II) Catalyzed Reactions of Direct and Enantioselective Aldol Reactions Catalyzed by Chiral Nickel(II) Complexes
Kennington, S. C. D.; Teloxa, S. F.; Mellado-Hidalgo, M.; Galeote, O.; Puddu, S.; Bellido, M.; Romea, P.; Urpí, F.; Aullón, G.; Font-Bardia, M.
Angew. Chem. Int. Ed. 2021, 60, 15307-15312.
79. Direct, Enantioselective, and Nickel(II) Catalyzed Reactions of N-Azidoacetyl Thioimides with Trimethyl Orthoformate. A New Combined Methodology for the Rapid Synthesis of Lacosamide and Derivatives
Teloxa, S. F.; Kennington, S. C. D.; Camats, M.; Romea, P.; Urpí, F.; Aullón, G.; Font-Bardia, M.
Chem. Eur. J. 2020, 26, 11540-11548.
78. Stereoselective Decarboxylative Alkylation of Titanium(IV) Enolates with Diacyl Peroxides
Gómez-Palomino, A.; Pérez-Palau, M.; Romea, P.; Urpí, F.; Del Olmo, M.; Hesse, T.; Fleckenstein, S.; Gómez-Benoga, E.; Sotorríos, L.; Font-Bardia, M.
Org. Lett. 2020, 22, 199-203.
77. Direct anti Glycolate Aldol Reaction of Protected Chiral N‐Hydroxyacetyl Thiazolidinethiones with Acetals Catalyzed by a Nickel(II) Complex
Romo, J. M.; Romea, P.; Urpí, F.
Eur. J. Org. Chem. 2019, 6296-6305.
76. Stereoselective Synthesis of Protected Peptides Containing an anti β-Hydroxy Tyrosine
Fernández-Valparis, J.; Romea, P.; Urpí, F.
Eur. J. Org. Chem. 2019, 2745-2752.
75. Direct and Asymmetric Nickel(II)-Catalyzed Construction of Carbon−Carbon Bonds from N‐Acyl Thiazinanethiones
Kennington, S. C. D.; Taylor, A. J.; Romea, P.; Urpí, F.; Aullón, G.; Font-Bardia, M.; Ferré, L.; Rodrigalvarez, J.
Org. Lett. 2019, 21, 305-309.
74. General and Stereoselective Aminoxylation of Biradical Titanium(IV) Enolates with TEMPO: a Detailed Study on the Effect of the Chiral Auxiliary
Kennington, S. C. D.; Gómez-Palomino, A.; Salomó, E.; Romea, P.; Urpí, F.; Font-Bardia, M.
Org. Biomol. Chem. 2018, 16, 4807-4815.
73. Stereoselective Oxidation of Titanium(IV) Enolates with Oxygen
Gómez-Palomino, A.; Romea, P.; Urpí, F.; Font-Bardia, M.
Synthesis 2018, 50, 2721-2726.
72. Stereoselective and Catalytic Synthesis of anti β-Alkoxy-α-Azido Carboxylic Derivatives
Fernández-Valparís,J.; Romea, P.; Urpí, F.; Font-Bardia, M.
Org. Lett. 2017, 19, 6400-6403.
71. Substrate–Controlled Michael Additions of Titanium Enolates from Chiral α-Benzyloxy Ketones to Conjugated Nitroalkenes
Gómez-Palomino, A.; Barrio, A.; García-Lorente, P.; Romea, P.; Urpí, F.; Font-Bardia, M.
Eur. J. Org. Chem. 2017, 5776-5784.
70. Experimental and Computational Evidence of the Biradical Structure and Reactivity of Titanium(IV) Enolates
Heras, C.; Gómez-Palomino, A.; Romea, P.; Urpí, F.; Bofill, J. M.; Moreira, I. de P. R.
J. Org. Chem. 2017, 82, 8980-8916.
69. Diastereoselective and Catalytic α-Alkylation of Chiral N-Acyl Thiazolidinethiones with Stable Carbocationic Salts
Kennington, S. C. D.; Ferrè, M.; Romo, J. M.; Romea, P.; Urpí, F.; Font-Bardia, M.
J. Org. Chem. 2017, 82, 6426-6433.
68. Total Synthesis of (+)-Herboxidiene/GEX 1A
Gómez-Palomino, A.; Pellicena, M.; Krämer, K.; Romea, P.; Urpí, F.; Aullón, G.; Padrón, J. M.
Org. Biomol. Chem. 2017, 15, 1842-1862.
67. Substrate-controlled Aldol Reactions from Chiral α-Hydroxy Ketones
Aullón, G.; Romea, P.; Urpí, F.
Synthesis 2017, 49, 474-503.
66. Stereoselective Synthesis of the C9–C19 Fragment of Peloruside A
Kennington, S.C.D.; Romo, J.M.; Romea, P.; Urpí, F.
Org. Lett. 2016, 18, 3018-3021.
65. Studies towards the synthesis of tedanolide C. Construction of the C13-epi C1–C15 fragment
Zambrana, J.; Romea, P.; Urpí, F.
Org. Biomol. Chem. 2016, 14, 5219-5223.
64. Stereoselective Alkylation of (S)-N-Acyl-4-isopropyl-1,3-thiazolidine-2-thiones Catalyzed by (Me3P)2NiCl2
Fernández-Valparís, J.; Romo, J. M.; Romea, P.; Urpí, F.; Kowalski, H.; Font-Bardia, M.
Org. Lett. 2015, 17, 3540-3543.
63. Kinetic resolution of esters from secondary and tertiary benzylic propargylic alcohols by an improved esterase-variant from Bacillus sp. BP-7
Fillat, A.; Romea, P.; Pastor, F. I. J.; Urpí, F.; Díaz, P.
Catalysis Today 2015, 255, 16-20.
62. Stereoselective Acetate Aldol Reactions of α-Silyloxy Ketones
Lorente, A.; Pellicena, M.; Romea, P.; Urpí, F.
Tetrahedron 2015, 71, 1023-1035.
61. Substrate-Controlled Michael Additions of Chiral Ketones to Enones
Fàbregas, M.; Gómez-Palomino, A.; Pellicena, M.; Reina, D. F.; Romea, P.; Urpí, F.; Font-Bardia, M.
Org. Lett. 2014, 16, 6220-6223.
60. Stereoselective Aminoxylation of Biradical Titanium Enolates with TEMPO
Gómez-Palomino, A.; Pellicena, M.; Romo, J. M.; Solà, R.; Romea, P.; Urpí, F.; Font-Bardia, M.
Chem. Eur. J. 2014, 20, 10153-10159.
59. Stereoselective Titanium-Mediated Aldol Reactions of a Chiral Lactate-Derived Ethyl Ketone with Ketones
Alcoberro, S.; Gómez-Palomino, A.; Solà, R.; Romea, P.; Urpí, F.; Font-Bardia, M.
Org. Lett. 2014, 16, 584-587.
58. Improving enantioselectivity towards tertiary alcohols using mutants of Bacillus sp. BP-7 esterase EstBP7 holding a rare GGG(X)-oxyanion hole
Fillat, A.; Romea, P.; Urpí, F.; Pastor, F. I. J.; Diaz, P.
Appl. Microbiol. Biotechnol. 2014, 98, 4479-4490.
57. Diastereoselective Methyl Orthoformate Alkylations of Chiral N-Acyl Thiazolidinethiones Catalyzed by Nickel(II) Complexes
Gálvez, E.; Romo, J. M.; Nubiola, I.; Romea, P.; Urpí, F.; Kindred, M.
Adv. Synth. Catal. 2013, 355, 2781-2786.
56. Stereoselective titanium-mediated aldol reactions from a chiral isopropyl ketone
Zambrana, J.; Romea, P.; Urpí, F.
Chem. Commun. 2013, 49, 4507-4509.
55. Stereoselective synthesis of C-glycosides by addition of titanium enolates from a chiral N-glycolyl thiazolidinethione to glycals
Gálvez, E.; Sau, M.; Romea, P.; Urpí, F.; Font-Bardia, M.
Tetrahedron Lett. 2013, 54, 1467-1470.
54. Stereoselective titanium-mediated aldol reactions of α-benzyloxy methyl ketones
Pellicena, M.; Solsona, J. G.; Romea, P.; Urpí, F.
Tetrahedron 2012, 68, 10338-10350.
53. Diastereoselective Additions of Titanium Enolates from N-Glycolyl Thiazolidinethiones to Acetals
Baiget, J.; Caba, M.; Gálvez, E.; Romea, P.; Urpí, F.; Font-Bardia, M.
J. Org. Chem. 2012, 77, 8809-8814.
52. Stereoselective Synthesis of protected 3-amino-3,6-dideoxyaminosugars
Nebot, J.; Romea, P.; Urpí, F.
Org. Biomol. Chem. 2012, 10, 6395-6403.
51. Total Synthesis of (+)-Herboxidiene from Two Chiral Lactate-derived Ketones
Pellicena, M.; Krämer, K.; Romea, P.; Urpí, F.
Org. Lett. 2011, 13, 5350-5353.
50. Highly Stereoselective Titanium-mediated Aldol Reaction from (S) 4-Benzyloxy-3-methyl-2-butanone
Zambrana, J.; Romea, P.; Urpí, F.; Luján, C.
J. Org. Chem. 2011, 76, 8575-8587.
49. Highly stereoselective titanium-mediated aldol reactions from chiral α-silyloxy ketones. A reliable tool for the synthesis of natural products
Esteve, J.; Jiménez, C.; Nebot, J.; Velasco, J.; Romea, P.; Urpí, F.
Tetrahedron 2011, 67, 6045-6056.
48. Stereoselective Acetate Aldol Reactions from Metal Enolates
Ariza, X.; Garcia, J.; Romea, P.; Urpí, F.
Synthesis 2011, 2175-2191.
47. Synthesis and Biological Evaluation of 1-Deoxy-5-hydroxysphingosine Derivatives
Esteve, J.; Lorente, A.; Romea, P.; Urpí, F.; Ríos-Luci,C.; Padrón, J. M.
Eur. J. Org. Chem. 2011, 960-967.
46. Highly Stereoselective Synthesis of syn-1,3-Diols through a Sequential Titanium-Mediated Aldol Reaction and LiBH4 Reduction
Esteve, J.; Matas, S.; Pellicena, M.; Velasco, J.; Romea, P.; Urpí, F.; Font-Bardia, M.
Eur. J. Org. Chem. 2010, 3146-3151.
45. 1,4-syn-Asymmetric induction in the titanium-mediated aldol reactions of chiral methyl α-silyloxy ketones
Lorente, A.; Pellicena, M.; Romea, P.; Urpí, F.
Tetrahedron Lett. 2010, 51, 942-945.
44. Stereoselective Synthesis of α- and β-C-Glycosides by Addition of Titanium Enolates to Glycals
Gálvez, E.; Larrosa, I.; Romea, P.; Urpí, F.
Synlett 2009, 2982-2986.
43. Stereoselective Synthesis of Highly Functionalized Structures from Lactate-Derived Halo Ketones
Nebot, J.; Romea, P.; Urpí, F.
J. Org. Chem. 2009, 74, 7518-7521.
42. New Approach to the Stereoselective Synthesis of Tertiary Methyl Ethers
Checa, B.; Gálvez, E.; Parelló, R.; Sau, M.; Romea, P.; Urpí, F.; Font-Bardia, M.; Solans, X.
Org. Lett. 2009, 11, 2193-2196.
41. Stereoselective Synthesis of anti α-Methyl-β-methoxy Carboxylic Compounds
Gálvez, E.; Romea, P.; Urpí, F.
Org. Synth. 2009, 86, 81-91.
40. Preparation of (S)-4-Isopropyl-N-propanoyl-1,3-thiazolidine-2-thione
Gálvez, E.; Romea, P.; Urpí, F.
Org. Synth. 2009, 86, 70-80.
39. Stereoselective addition of titanium enolates to functionalized acetals. A novel approach to the γ-amino acids of bistramides and FR252921
Gálvez, E.; Parelló, R.; Romea, P.; Urpí, F.
Synlett 2008, 2951-2954.
38. 1,4-Asymmetric induction in the titanium-mediated aldol reactions of α-benzyloxy methyl ketones
Pellicena, M.; Solsona, J. G.; Romea, P.; Urpí, F.
Tetrahedron Lett. 2008, 49, 5265-5267.
37. On the influence of chiral auxiliaries in the stereoselective cross-coupling reactions of titanium enolates and acetals
Baiget, J.; Cosp, A.; Gálvez, E.; Gómez-Pinal, L ; Romea, P.; Urpí, F.
Tetrahedron 2008, 64, 5637-5644.
36. Unconventional Biradical Character of Titanium Enolates
Moreira, I. de P. R.; Bofill, J. M.; Anglada, J. M.; Solsona, J. G.; Nebot, J.; Romea, P.; Urpí, F.
J. Am. Chem. Soc. 2008, 130, 3242-3243.
35. Synthesis of six-membered oxygenated heterocycles through carbon-oxygen bond-forming reactions
Larrosa, I.; Romea, P.; Urpí, F.
Tetrahedron 2008, 64, 2683-2723.
34. Highly Stereoselective TiCl4-Mediated Aldol Reactions from (S)-2-Benzyloxy-3-pentanone
Rodríguez-Cisterna, V.; Villar, C.; Romea, P.; Urpí, F.
J. Org. Chem. 2007, 72, 6631-6633.
33. Stereoselective titanium-mediated aldol reaction of (S)-2-tert-butyldimethylsilyloxy-3-pentanone
Nebot, J.; Figueras, S.; Romea, P.; Urpí, F.; Ji, Y.
Tetrahedron 2006, 62, 11090-11099.
32. Synthesis of the C9-C21 fragment of debromaplysiatoxin and oscillatoxins A and D
Cosp, A.; Llàcer, E.; Romea, P.; Urpí, F.
Tetrahedron. Lett. 2006, 47, 5819-5823.
31. Studies on the hydrogenolysis of benzyl ethers
Llàcer, E.; Romea, P.; Urpí, F.
Tetrahedron. Lett. 2006, 47, 5815-5818.
30. Stereoselective Synthesis of the Western Hemisphere of Salinomycin
Larrosa, I.; Romea, P.; Urpí, F.
Org. Lett. 2006, 8, 527-530.
29. Highly stereoselective aldol reaction based on titanium enolates from (S)-1-benzyloxy-2-methyl-3-pentanone
Solsona, J. G.; Nebot, J.; Romea, P.; Urpí, F.
J. Org. Chem. 2005, 70, 6533-6536.
28. A stereoselective aldol-reduction approach to polyoxygenated natural products. Synthesis of C1-C6 fragment of erythronolides
Galobardes, M.; Gascón, M.; Romea, P.; Urpí, F.
Lett. Org. Chem. 2005, 2, 312-315.
27. Double Stereodifferentiating Aldol Reactions Based on Chiral Ketones Derived from Lactic Acid: Synthesis of C1-C6 Fragment of Erythronolides
Solsona, J. G.; Nebot, J.; Romea, P.; Urpí, F.
Synlett 2004, 2127-2130.
26. Stereoselective titanium-mediated syn-aldol reaction from a lactate-derived chiral ethyl ketone
Solsona, J. G.; Romea, P.; Urpí, F.
Tetrahedron Lett. 2004, 45, 5379-5382.
25. Studies Directed toward the Construction of Polypropionate Fragment of Superstolide A
Solsona, J. G.; Romea, P.; Urpí, F.
Org. Lett. 2003, 5, 4681-4684.
24. Studies on the Intramolecular CH···X (X= O, S) Interactions in (S)-N-Acyl-4-isopropyl-1,3-thiazolidine-2-thiones and Related 1,3-Oxazolidin-2-ones
Cosp, A.; Larrosa, I.; Anglada, J. M.; Bofill, J. M.; Romea, P.; Urpí, F.
Org. Lett. 2003, 5, 2809-2812.
23. Synthesis of O-Benzyl Protected anti Aldols through the Cross-Coupling Reaction of Dibenzyl Acetal with a Chiral Titanium Enolate
Cosp, A.; Larrosa, I.; Vilasís, I.; Romea, P.; Urpí, F.; Vilarrasa, J.
Synlett 2003, 1109-1112.
22. Highly Stereoselective Aldol Reaction of Titanium Enolates from Lactate-Derived Chiral Ketones
Solsona, J. G.; Romea, P.; Urpí, F.; Vilarrasa, J.
Org. Lett. 2003, 5, 519-522.
21. Unprecedented Highly Stereoselective α- and β-C-Glycosidation with Chiral Titanium Enolates
Larrosa, I.; Romea, P.; Urpí, F.; Balsells, D.; Vilarrasa, J.; Font-Bardia, M.; Solans, X.
Org. Lett. 2002, 4, 4651-4654.
20. Stereoselective synthesis of syn,syn-2-methyl-1,3-diols through one pot aldol-reduction sequence
Galobardes, M.; Mena, M.; Romea, P.; Urpí, F.; Vilarrasa, J.
Tetrahedron Lett. 2002, 43, 6145-6148.
19. β3-Amino acids by nucleophilic ring-opening of N-nosyl aziridines
Farràs, J.; Ginesta, X.; Sutton, P.; Taltavull, J.; Egeler, F.; Romea, P.; Urpí, F.; Vilarrasa, J.
Tetrahedron 2001, 57, 7665-7674.
18. Enantiopure β-methoxy carboxyl derivatives from a chiral titanium enolate and dimethyl acetals
Cosp, A.; Romea, P.; Urpí, F.; Vilarrasa, J.
Tetrahedron Lett. 2001, 42, 4629-4631.
17. Enantioselective Addition of a Chiral Thiazolidinethione-Derived Titanium Enolate to Acetals
Cosp, A.; Romea, P.; Talavera, P.; Urpí, F.; Vilarrasa, J.; Font-Bardia, M.; Solans, X.
Org. Lett. 2001, 3, 615-617.
16. Simple and Efficient Preparation of Enantiopure Alkyl α-Hydroxyalkyl Ketones
Ferreró, M.; Galobardes, M.; Martín, R.; Montes, T.; Romea, P.; Rovira, R.; Urpí, F.; Vilarrasa, J.
Synthesis 2000, 1608-1614.
15. Pseudoaxially Disubstituted Cyclo-β3-tetrapeptide Scaffolds
Sutton, P. W.; Bradley, A.; Farràs, J.; Romea, P.; Urpí, F.; Vilarrasa, J.
Tetrahedron 2000, 56, 7947-7958.
14. Enolization of Chiral α-Silyloxy Ketones with Dicyclohexylchloroborane. Application to Stereoselective Aldol Reactions
Galobardes, M.; Gascón, M.; Mena, M.; Romea, P.; Urpí, F.; Vilarrasa, J.
Org. Lett. 2000, 2, 2599-2602.
13. Reaction of Chiral Titanium Z-Enolates with Chiral α-Silyloxy Aldehydes. Syntheses of NFX-2 and Antimycinone
Esteve, C.; Ferreró, M.; Romea, P.; Urpí, F.; Vilarrasa, J.
Tetrahedron Lett. 1999, 40, 5083-5086.
12. Reaction of Achiral Titanium Z-Enolates with Chiral α-Silyloxy Aldehydes
Esteve, C.; Ferreró, M.; Romea, P.; Urpí, F.; Vilarrasa, J.
Tetrahedron Lett. 1999, 40, 5079-5082.
11. Design and synthesis of a novel cyclo-β-tetrapeptide
Sutton, P. W.; Bradley, A.; Elsegood, M. R. J.; Farràs, J.; Jackson, R. F. W.; Romea, P.; Urpí, F.; Vilarrasa, J.
Tetrahedron Lett. 1999, 40, 2629-2632.
10. Syntheses of the C-1 alkyl side chains of Zaragozic acids A and C
Bach, J.; Galobardes, M.; García, J.; Romea, P.; Tey, C.; Urpí, F.; Vilarrasa, J.
Tetrahedron Lett. 1998, 39, 6765-6768.
9. Simple and Efficient Preparation of Ketones from Morpholine Amides
Martín, R.; Romea, P.; Tey, C.; Urpí, F.; Vilarrasa, J.
Synlett 1997, 1414-1416.
8. Highly Stereoselective Aldol Reactions of Titanium Enolates from Ethyl α-Silyloxyalkyl Ketones
Figueras, S.; Martín, R.; Romea, P.; Urpí, F.; Vilarrasa, J.
Tetrahedron Lett. 1997, 38, 1637-1640.
7. A Simple Procedure for the Preparation of Enantiopure Ethyl α-Hydroxyalkyl Ketones
Martín, R.; Pascual, O.; Romea, P.; Rovira, R.; Urpí, F.; Vilarrasa, J.
Tetrahedron Lett. 1997, 38, 1633-1636.
6. Studies in Macrolide Synthesis: A Stereocontrolled Synthesis of Oleandolide Employing Reagent- and Substrate-Controlled Aldol Reactions of (S)-1-(Benzyloxy)-2-methylpentan-3-one
Paterson, I.; Norcross, R. D.; Ward, R. A.; Romea, P.; Lister, M. A.
J. Am. Chem. Soc. 1994, 116, 11287-11314.
5. Substrate-Controlled Aldol Reactions of Chiral Ethyl Ketones; Application to the Total Synthesis of Oleandomycin
Paterson, I.; Ward, R. A.; Romea, P.; Norcross, R. D.
J. Am. Chem. Soc. 1994, 116, 3623-3624.
4. Alternative Procedures for the Macrolactamisation of ω-Azido Acids
Bosch, I.; Romea, P.; Urpí, F.; Vilarrasa, J.
Tetrahedron Lett. 1993, 34, 4671-4674.
3. Improved Methods for the N-Nitration of Amides
Romea, P.; Aragonès, M.; García, J.; Vilarrasa, J.
J. Org. Chem. 1991, 56, 7038-7042.
2. A Fast Procedure for the Reduction of Azides and Nitro Compounds Based on the Reducing Ability of Sn(SR)3- Species
Bartra, M.; Romea, P.; Urpí, F.; Vilarrasa, J.
Tetrahedron 1990, 46, 587-594.
1. Nitrosation of Hindered Amides
Romea, P.; Urpí, F.; Vilarrasa, J.
J. Org. Chem. 1989, 54, 3209-3211.

Miembro de:

Reconocimiento internacional de la excelencia